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Original Article

Prevalence, patterns, risk factors and outcomes of peritoneal metastases after laparoscopic hepatectomy for hepatocellular carcinoma: a multicenter study from China
Yuan-Xiang Lu, Jian-Ping Zhao, Guan-Dou Yuan, Ming-Gen Hu, Chuan-Dong Sun, Kun-Lun Chen, Yao Chen, Yong-Yi Zeng, Zhi-Ying Yang, Wan-Guang Zhang
Laparoscopic hepatectomy was not associated with increased prevalence of peritoneal metastases in hepatocellular carcinoma patients for experienced surgeons. Surgical re-excision of peritoneal metastases could benefit long term survival.
Grading severity of microscopic vascular invasion was independently associated with recurrence and survival following hepatectomy for solitary hepatocellular carcinoma
Lan-Qing Yao, Chao Li, Yong-Kang Diao, Lei Liang, Hang-Dong Jia, Shi-Chuan Tang, Yong-Yi Zeng, Han Wu, Ming-Da Wang, Li-Hui Gu, Timothy M. Pawlik, Wan Yee Lau, Cheng-Wu Zhang, Feng Shen, Kui Wang, Tian Yang

Review Article

Molecular pathology for cholangiocarcinoma: a review of actionable genetic targets and their relevance to adjuvant & neoadjuvant therapy, staging, follow-up, and determination of minimal residual disease
Emilie A. K. Warren, Shishir K. Maithel
Molecular profiling has revealed a wealth of targetable genetic alterations in cholangiocarcinoma, prompting numerous clinical trials employing targeted drugs. This review summarizes the progress of those trials, while emphasizing the importance of further study in the adjuvant and neoadjuvant space.
Existing and emerging biomarkers in hepatocellular carcinoma: relevance in staging, determination of minimal residual disease, and monitoring treatment response: a narrative review
Dana A. Dominguez, Paul Wong, Laleh G. Melstrom
This narrative review examines the existing literature describing current and future biomarkers in hepatocellular carcinoma throughout the different phases of management: 1) screening, 2) risk stratification, 3) detection of minimal residual disease, 4) post resection surveillance and 5) prediction of tumor sensitivity to therapy.
Molecular pathology and protein markers for pancreatic cancer: relevance in staging, in adjuvant therapy, in determination of minimal residual disease, and follow-up
Caitlin P. Sok, Karunesh Polireddy, David A. Kooby
The use of circulating protein biomarkers to diagnose, predict prognosis, and detect the recurrence of pancreatic ductal adenocarcinoma is attractive because it is minimally invasive and cost-effective. This review highlights circulating protein biomarkers that are currently in clinical use or under study for pancreatic cancer.
Management of hepatocellular carcinoma recurrence after liver surgery and thermal ablations: state of the art and future perspectives
Astrid Herrero, Cyprien Toubert, Jose Ursic Bedoya, Eric Assenat, Boris Guiu, Fabrizio Panaro, Thomas Bardol, Gianluca Cassese
Recurrence is a major issue after HCC treatment, with different timing and location patterns. Their deep knowledge is needed to carry out the timeliest treatment. There is still debate about the best treatment to perform. Interesting future perspectives deserve to be further discussed and investigated.

Expert Consensus

International consensus guidelines on robotic pancreatic surgery in 2023
Rong Liu, Mohammed Abu Hilal, Marc G. Besselink, Thilo Hackert, Chinnusamy Palanivelu, Yupei Zhao, Jin He, Ugo Boggi, Jin-Young Jang, Fabrizio Panaro, Brian K. P. Goh, Mikhail Efanov, Yuichi Nagakawa, Hong-Jin Kim, Xiaoyu Yin, Zhiming Zhao, Yi-Ming Shyr, Shridhar Iyer, Eli Kakiashvili, Ho-Seong Han, Jae Hoon Lee, Roland Croner, Shin-E Wang, Marco Vito Marino, Arun Prasad, Wei Wang, Songqing He, Kehu Yang, Qu Liu, Zizheng Wang, Mengyang Li, Shuai Xu, Kongyuan Wei, Zhaoda Deng, Yuze Jia, Tess M. E. van Ramshorst
This international consensus guidelines on robotic pancreatic surgery (RPS) summarize the latest RPS literature, bringing together the opinions and recommendations of 29 Eastern and Western experts on 19 clinical issues. These recommendations offer comprehensive advice on indications, safety, and efficacy of different types of RPS.

Editorial Commentary

A journey of a thousand miles begins with one small step
Elke Roeb
Heterogeneity in the risk of incident liver cirrhosis driven by PNPLA3 genotype and diabetes among different populations
Bo Kyung Koo, Dong Hyeon Lee, Jeong Hwan Park, Won Kim
The global burden of fatty liver disease: the major impact of China
Tian-Wen Lou, Rui-Xu Yang, Jian-Gao Fan
The importance of age for liver-related mortality in patients with metabolic-dysfunction associated steatotic liver disease
Einar S. Bjornsson
Advancing towards accurate phenotyping based on metabolic and fibrosis risk in metabolic-dysfunction associated steatotic liver disease: one step closer to personalized care
Sergio Muñoz-Martínez, Alba Jiménez-Masip, Juan M. Pericàs
Shrinking fat, healing liver: unlocking the metabolic dysfunction associated steatohepatitis puzzle
Sudhakar K. Venkatesh, Ilkay S. Idilman, Jiahui Li, Meng Yin
The antiviral treatment should be initiated before the development of cirrhosis
Qiao Tang, Peng Hu
A novel use of the comprehensive complication index in perihilar cholangiocarcinoma surgery
Edoardo Poletto, Simone Conci, Tommaso Campagnaro, Mario De Bellis, Laura Alaimo, Andrea Ruzzenente
Liver transplantation for primary sclerosing cholangitis—morbidities including disease recurrence
Nobuhisa Akamatsu
Proteome profiling to advance management of metabolic dysfunction-associated fatty liver disease
Mohammed Eslam, Nahum Méndez-Sánchez, Ming-Hua Zheng
Relationship between portal hypertension and liver stiffness measurements in the treatment of hepatocellular carcinoma from the surgeon’s point of view in the Baveno VII era
Nobuyuki Takemura, Norihiro Kokudo
Assessment of morbidity and mortality after liver transplantation for primary sclerosing cholangitis
Burcin Ekser, Plamen Mihaylov, Richard S. Mangus
Primary liver cancer spectrum: current knowledge and the next steps
Mohammad Saeid Rezaee-Zavareh, Ekaterina K. Koltsova, Yujin Hoshida, Ju Dong Yang
Impact of low alcohol consumption in the natural history of cirrhosis
David Marti-Aguado, Eduardo Vilar-Gomez
Clinical feasibility of modified extended left hemihepatectomy in advanced perihilar cholangiocarcinoma
Hye-Sung Jo, Dong-Sik Kim
Insights into treatment for hepatocellular carcinoma with tumor thrombus in the inferior vena cava or right atrium
Jia Yang, Yongjie Shui, Lihong Liu, Genhua Yu, Qichun Wei
Primary sclerosing cholangitis and cholangiocarcinoma: the 2023 practice guidance and future perspectives
Francesca Saffioti, Vasileios K. Mavroeidis
Lean individuals with nonalcoholic fatty liver disease, the chicken or the egg?
Eugene Han, Yong-ho Lee
The current status and reflections on 3D in vitro modeling of liver metastasis in colorectal cancer
Bo Zhou, Minghao Sun, Mian Yang, Wei Cui, Huayu Yang

Review Article

Histamine regulation of pancreatitis and pancreatic cancer: a review of recent findings
Taylor Francis, Allyson Graf, Kyle Hodges, Lindsey Kennedy, Laura Hargrove, Mattie Price, Kate Kearney, Heather Francis
Liver transplantation for hepatocellular carcinoma
Jerome Byam, John Renz, J. Michael Millis
Hilar cholangiocarcinoma: diagnosis, treatment options, and management
Kevin C. Soares, Ihab Kamel, David P. Cosgrove, Joseph M. Herman, Timothy M. Pawlik

Original Articles

Correlation between 3D-MRCP and intra-operative findings in right liver donors
Aly Ragab, Reyold I. Lopez-Soler, Aytekin Oto, Giuliano Testa
Diagnosis and treatment of hepatic angiomyolipoma
Shunda Du, Ying Li, Yilei Mao, Xinting Sang, Xin Lu, Wenze Wang, Qing Zhang, Huadan Xue, Xiaobo Yang, Shaohua Li, Tianyi Chi, Shouxian Zhong, Jiefu Huang
Liver transplantation in mainland China: the overview of CLTR 2011 annual scientific report
Haibo Wang, Wenshi Jiang, Zhiye Zhou, Jianyan Long, Wen Li, Sheung Tat Fan
Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats
Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang

Original Article

Inhibition of the liver expression of arylalkylamine N-acetyltransferase increases the expression of angiogenic factors in cholangiocytes
Anastasia Renzi, Romina Mancinelli, Paolo Onori, Antonio Franchitto, Gianfranco Alpini, Shannon Glaser, Eugenio Gaudio

Review Article

Melatonin regulation of biliary functions
Shannon Glaser, Yuyan Han, Heather Francis, Gianfranco Alpini

Editorials

Risk stratification for Hepatitis B treatment in the molecular age
Sanjay R. Mehta, Alexander Kuo

Original Articles

Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats
Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang
Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions
Antonio J. Melendez-Martinez, Andre F. Nascimento, Yan Wang, Chun Liu, Yilei Mao, Xiang-Dong Wang

Review Articles on Liver Immunology: Part 2

Contribution of bone marrow-derived fibrocytes to liver fibrosis
Jun Xu, Min Cong, Tae Jun Park, David Scholten, David A. Brenner, Tatiana Kisseleva

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 1

Inhibition of diethylnitrosamine-initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice
Bruna Paola Murino Rafacho, Camilla Peach Stice, Chun Liu, Andrew S. Greenberg, Lynne M. Ausman, Xiang-Dong Wang

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 2

DGAT1-deficiency affects the cellular distribution of hepatic retinoid and attenuates the progression of CCl4-induced liver fibrosis
Jason J. Yuen, Seung-Ah Lee, Hongfeng Jiang, Pierre-Jacques Brun, William S. Blaner

Review Article on Retinoid Biology: Part I

STRA6: role in cellular retinol uptake and efflux
Mary Kelly, Johannes von Lintig

Original Article on Retinoid Biology: Part I

Alcohol exposure in utero perturbs retinoid homeostasis in adult rats
Youn-Kyung Kim, Michael V. Zuccaro, Changqing Zhang, Dipak Sarkar, Loredana Quadro

Below are the latest Hepatobiliary Surgery and Nutrition articles published online ahead of print publication.

Original Article
Association of Pringle maneuver with postoperative recurrence and survival following hepatectomy for hepatocellular carcinoma: a multicenter propensity score and competing-risks regression analysis
Shi-Chuan Tang, Yong-Kang Diao, Kong-Ying Lin, Chao Li, Xiao Xu, Lei Liang, Jie Kong, Qing-Jing Chen, Xian-Ming Wang, Fu-Bao Liu, Wei-Min Gu, Ya-Hao Zhou, Ying-Jian Liang, Hong-Zhi Liu, Ming-Da Wang, Lan-Qing Yao, Timothy M. Pawlik, Feng Shen, Wan Yee Lau, Tian Yang, Yong-Yi Zeng
Published online: 05 July 2023
Original Article
A combined pre- and intra-operative nomogram in evaluation of degrees of liver cirrhosis predicts post-hepatectomy liver failure: a multicenter prospective study
Bin-Yong Liang, Er-Lei Zhang, Jian Li, Xin Long, Wen-Qiang Wang, Bi-Xiang Zhang, Zhi-Wei Zhang, Yi-Fa Chen, Wan-Guang Zhang, Bin Mei, Zhen-Yu Xiao, Jin Gu, Zun-Yi Zhang, Shuai Xiang, Han-Hua Dong, Lei Zhang, Peng Zhu, Qi Cheng, Lin Chen, Zhan-Guo Zhang, Bin-Hao Zhang, Wei Dong, Xiao-Feng Liao, Tao Yin, Dong-De Wu, Bin Jiang, Yu-Feng Yuan, Zhong-Lin Zhang, Yao-Bing Chen, Kai-Yan Li, Wan Yee Lau, Xiao-Ping Chen, Zhi-Yong Huang
Published online: 15 March 2023